Journal: iScience

Article Title: IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

doi: 10.1016/j.isci.2025.112567

Figure Lengend Snippet: Activation of p53 by IMPDH inhibition is dependent on RS (A) Immunoblot of WaGa cells treated with MPA (1 μM) for indicated times. Representative of 3 independent experiments. (B) Immunoblot of WaGa cells treated with MPA (1 μM) and guanosine (10 μM) for 24 h. Representative of 3 independent experiments. (C) Immunoblot of WaGa cells treated for 24 h with MPA (1 μM) concurrent with inhibitors for ATR (250 nM; berzosertib), ATM (10 μM; KU55933), DNA-PK (10 μM; AZD7648) or with all three inhibitors combined (3x). Representative of 3 independent experiments. For panels A-C, the total KAP1 blot is a reblot of the pKAP1 blot, the total CHK1 blot is a reblot of pCHK1, and the total CHK2 blot is a reblot of pCHK2.

Article Snippet: pCHK2 (Thr68; C13C1) , Cell Signaling Technology , CAT# 2197; RRID: AB_2080501.

Techniques: Activation Assay, Inhibition, Western Blot

Journal: NAR Cancer

Article Title: PARP inhibitor response is enhanced in prostate cancer when XRCC1 expression is reduced

doi: 10.1093/narcan/zcaf015

Figure Lengend Snippet: Antibodies used for immunoblotting experiments

Article Snippet: pCHK2-T68 (#2197) , 1:500 , Cell Signaling Technology.

Techniques: Western Blot